Structure of PDB 6szu Chain C Binding Site BS01

Receptor Information

>6szu Chain C (length=249) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPG

Ligand information

>6szu Chain V (length=44)

aguaguaacaagagcaauguguccgucucgccucugcuucugcu

.<<....>>...................................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6szu A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase.
• Resolution: 2.41 Å
• Binding residue (original residue number in PDB): R38 A52 M53 K54 Y55 T81 K82 D83 A84 R88 I201 R216
• Binding residue (residue number reindexed from 1): R40 A54 M55 K56 Y57 T83 K84 D85 A86 R90 I203 R218

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:6szu, PDBe:6szu, PDBj:6szu
• PDBsum: 6szu
• PubMed: 32304664
• UniProt: H6QM90