Structure of PDB 6sof Chain C Binding Site BS01

Receptor Information
>6sof Chain C (length=719) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLL
CTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNL
AAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSF
YALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKG
RQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDL
LGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLD
PISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESS
FRKTFEDYLHNVVFVPRPS
Ligand information
>6sof Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GIVEQCCTSICSLYQLENYCN
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6sof Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		R498 N711 F714 S719
Binding residue
(residue number reindexed from 1)		R498 N711 F714 S719
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
External links
PDB RCSB:6sof, PDBe:6sof, PDBj:6sof
PDBsum6sof
PubMed31727777
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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