Structure of PDB 6sk7 Chain C Binding Site BS01

Receptor Information
>6sk7 Chain C (length=214) Species: 650130 (Human rhinovirus 89 ATCC VR-1199) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPSAFPYFHPTKEIFIPGQVRNLIEMCQVDTLIPVNNTQENVRSVNMYTV
DLRTQVDLAKEVFSIPVDIASQPLATTLIGELASYYTHWTGSLRFSFMFC
GSASSTLKLLIAYTPPGVGKPKSRREAMLGTHLVWDVGLQSTASLVVPWV
SASHFRFTTPDTYSSAGYITCWYQTNFVVPDSTPDNAKMVCMVSACKDFC
LRLARDTNLHTQEG
Ligand information
>6sk7 Chain D (length=17) Species: 650130 (Human rhinovirus 89 ATCC VR-1199) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NINYFKDAASSGASRLD
Receptor-Ligand Complex Structure
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PDB6sk7 Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S21 P22 S23
Binding residue
(residue number reindexed from 1)		S1 P2 S3
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity

View graph for
Molecular Function
External links
PDB RCSB:6sk7, PDBe:6sk7, PDBj:6sk7
PDBsum6sk7
PubMed31462495
UniProtP07210|POLG_HRV8A Genome polyprotein

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