Structure of PDB 6sje Chain C Binding Site BS01

Receptor Information
>6sje Chain C (length=1121) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLRVYHSNRLDVLEALMEFIVERERLDDPFEPEMILVQSTGMAQWLQMTL
SQKFGIAANIDFPLPASFIWDMFVRVLPEIPKESAFNKQSMSWKLMTLLP
QLLEREDFTLLRHYLTDDSDKRKLFQLSSKAADLFDQYLVYRPDWLAQWE
TGHLVEGLGEAQAWQAPLWKALVEYTHQLGQPRWHRANLYQRFIETLESA
TTCPPGLPSRVFICGISALPPVYLQALQALGKHIEIHLLFTNPCRYYWGD
IKDPAYLAKLLTRQRRHSFEDRELPLFRDSENAGQLFNSDGEQDVGNPLL
ASWGKLGRDYIYLLSDLESSQELDAFVDVTPDNLLHNIQSDILELENRAV
AGVNIEEFSRSDNKRPLDPLDSSITFHVCHSPQREVEVLHDRLLAMLEED
PTLTPRDIIVMVADIDSYSPFIQAVFGSAPADRYLPYAISDRRARQSHPV
LEAFISLLSLPDSRFVSEDVLALLDVPVLAARFDITEEGLRYLRQWVNES
GIRWGIDDDNVRELELPATGQHTWRFGLTRMLLGYAMESAQGEWQSVLPY
DESSGLIAELVGHLASLLMQLNIWRRGLAQERPLEEWLPVCRDMLNAFFL
PDAETEAAMTLIEQQWQAIIAEGLGAQYGDAVPLSLLRDELAQRLDQERI
SQRFLAGPVNICTLMPMRSIPFKVVCLLGMNDGVYPRQLAPLGFDLMSQK
PKRGDRSRRDDDRYLFLEALISAQQKLYISYIGRSIQDNSERFPSVLVQE
LIDYIGQSHYLPGDEALNCDESEARVKAHLTCLHTRMPFDPQNYQPGERQ
SYAREWLPAASQAGKAHSEFVQPLPFTLPETVPLETLQRFWAHPVRAFFQ
MRLQVNFRTEDSEIPDTEPFILEGLSRYQINQQLLNALVEQDDAERLFRR
FRAAGDLPYGAFGEIFWETQCQEMQQLADRVIACRQPGQSMEIDLACNGV
QITGWLPQVQPDGLLRWRPSLLSVAQGMQLWLEHLVYCASGGNGESRLFL
RKDGEWRFPPLAAEQALHYLSQLIEGYREGMSAPLLVLPESGGAWLKTCY
DAQNDAMLDDDSTLQKARTKFLQAYEGNMMVRGEGDDIWYQRLWRQLTPE
TMEAIVEQSQRFLLPLFRFNQ
Ligand information
>6sje Chain X (length=68) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ttttttttttttgagcgactgcactacaacgttgtagtgcagtcgctctt
ttttttgctggtggtttt
Receptor-Ligand Complex Structure
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PDB6sje A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		F62 L64 P65 A66 S67 W70 K82 S84 D133 D136 Q137 V140 R186 R443 R649 I650 Q652 R653 T663 M665 P666 R687 R706 R708 D712 R846 L875 Y878 R968 S970 L971 N1078 M1079 M1080 V1081
Binding residue
(residue number reindexed from 1)		F62 L64 P65 A66 S67 W70 K82 S84 D133 D136 Q137 V140 R186 R443 R649 I650 Q652 R653 T663 M665 P666 R687 R706 R708 D712 R846 L875 Y878 R968 S970 L971 N1078 M1079 M1080 V1081
Enzymatic activity
Enzyme Commision number 3.1.11.5: exodeoxyribonuclease V.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008854 exodeoxyribonuclease V activity
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0009314 response to radiation
GO:0032508 DNA duplex unwinding
GO:0044355 clearance of foreign intracellular DNA
Cellular Component
GO:0009338 exodeoxyribonuclease V complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6sje, PDBe:6sje, PDBj:6sje
PDBsum6sje
PubMed31907455
UniProtP07648|RECC_ECOLI RecBCD enzyme subunit RecC (Gene Name=recC)

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