Structure of PDB 6rxr Chain C Binding Site BS01

Receptor Information
>6rxr Chain C (length=225) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVGTPEGFDRDPELVQ
AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNCDNLHERAG
NTNVIHMHGELLKVRCSQSGQALDWTGDVTPEPLRPHVVWFGEMPLGMDE
IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE
FAEKYYGPASQVVPEFVEKLLKGLK
Ligand information
>6rxr Chain G (length=9) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GGAKRHRKI
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rxr Evolved, Selective Erasers of Distinct Lysine Acylations.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		V188 F190 G191 E192 M193 Y201 H218 V219 Y220 P221
Binding residue
(residue number reindexed from 1)		V139 F141 G142 E143 M144 Y152 H169 V170 Y171 P172
Enzymatic activity
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6rxr, PDBe:6rxr, PDBj:6rxr
PDBsum6rxr
PubMed32187803
UniProtP75960|NPD_ECOLI NAD-dependent protein deacylase (Gene Name=cobB)

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