Structure of PDB 6rqc Chain C Binding Site BS01

Receptor Information
>6rqc Chain C (length=582) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FADAQRSHYTVYPSLPQSNKNDKHIPFVKLLSGKESEVNVEKRWELYHQL
HSHFHDQVDHIIDNIEADLKAEISDLLYSETTQKRRCFNTIFLLGSDSTT
KIELKDESSRYNVLIELTPKESPNVRMMLRRSMYKLYSAADAEEHNDVSY
DLSLVENFKRLFGKDLAMVFNFKDVDSINFNTLDNFIILLKSAFKYDHVK
ISLIFNINTNLSNIEKNLRQSTIRLLKRNYHKLDVSSNKGFKYGNQIFQS
FLDTVDGKLNLSDRFVEFILSKMANNTNHNLQLLTKMLDYSLMSYFFQNA
FSVFIDPVNVDFLNDDYLKILSRCPTFMFFVEGLIKQHAPADEILSLLTN
KNRGLEEFFVEFLVRENPINGHAKFVARFLEEELNITNFNLIELYHNLLI
GKLDSYLDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIFPSY
KSNIEDNLLSWEQVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYREANM
TINIYDFYIAFRETLPKEEILNFIRKDPSNTKLLELAETPDAFDKVALIL
FMQAIFAFENMGLIKFQSTKSYDLVEKCVWRG
Ligand information
>6rqc Chain X (length=88) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tggtttttatatgttttgttatgtattgtttattttcccttgactgactg
actgactgactgactgactgactgactgactgtatata
Receptor-Ligand Complex Structure
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PDB6rqc Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM.
Resolution4.4 Å
Binding residue
(original residue number in PDB)
M141 R144
Binding residue
(residue number reindexed from 1)
M127 R130
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:6rqc, PDBe:6rqc, PDBj:6rqc
PDBsum6rqc
PubMed31748745
UniProtP54790|ORC3_YEAST Origin recognition complex subunit 3 (Gene Name=ORC3)

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