Structure of PDB 6rjd Chain C Binding Site BS01

Receptor Information
>6rjd Chain C (length=831) Species: 1268061 (Streptococcus thermophilus DGCC 7710) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQG
RRLTRRKKHRRVRLNRLFEESGLITDFTKISINLNPYQLRVKGLTDELSN
EELFIALKNMVKHRGISYLDGDYAQIVKENSKQLETKTPGQIQLERYQTY
GQLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFI
NRYLEILTGKRKYYHGPGNEKSRTDYGRYRTSGETLDNIFGILIGKCTFY
PDEFRAAKASYTAQEFNLLNDLNNLTVLSKEQKNQIINYVKNEKAMGPAK
LFKYIAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMD
RETLDKLAYVLTLNTEREGIQEALEHEFADGSFSQKQVDELVQFRKANSS
IFGKGWHNFSVKLMMELIPELYETSEEQMTILTRLGKQKTTSSSNKTKYI
DEKLLTEEIYNPVVAKSVRQAIKIVNAAIKEYGDFDNIVIEMASRVVLNA
LQEHFRAHKIDTKVSVHHHAVDALIIAASSEDSILFSYQVDSKFNRKISD
ATIYATRQAKVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLM
YRHDPQTFEKVIEPILENPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDS
KLGNHIDITPKDSNNKVVLQSVSPWRADVYFNKTTGKYEILGLKYADLQF
EKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQ
LFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLG
KSNISIYKVRTDVLGNQHIIKNEGDKPKLDF
Ligand information
>6rjd Chain D (length=78) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugcguugauaaaaguauuguuuuuguacucuagaagcuacaaagauaag
gcuucaugccgaaaucaacaccgguguu
...................<<<<<<<<<.<<<>>>...>>>>>>>>>..<
<<.....>>>......<<<<....>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6rjd Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N42 R46 R47 N49 R53 R54 L55 R57 R58 K60 H61 R63 R68 I84 N85 Y89 K110 R116 G163 R166 G167 R223 Y225 G228 P229 N231 K233 S234 Y238 Y241 N279 R338 K341 H348 H425 N426 F427 Q446 M447 K466 K484 K491 V814 N819 R820 I822 I827 A829 R831 M874 H877 D878 K922 S924 K925 P930 E931 K933 S934 L935 N954 F990 K992 R1100 D1102 H1108
Binding residue
(residue number reindexed from 1)		N40 R44 R45 N47 R51 R52 L53 R55 R56 K58 H59 R61 R66 I82 N83 Y87 K108 R114 G151 R154 G155 R211 Y213 G216 P217 N219 K221 S222 Y226 Y229 N267 R320 K323 H330 H407 N408 F409 Q428 M429 K448 K466 K473 V540 N545 R546 I548 I553 A555 R557 M600 H603 D604 K632 S634 K635 P640 E641 K643 S644 L645 N664 F700 K702 R810 D812 H818
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6rjd, PDBe:6rjd, PDBj:6rjd
PDBsum6rjd
PubMed31604602
UniProtQ03LF7|CAS9A_STRTD CRISPR-associated endonuclease Cas9 1 (Gene Name=cas9-1)

[Back to BioLiP]