Structure of PDB 6qzv Chain C Binding Site BS01

Receptor Information
>6qzv Chain C (length=808) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PAARFQVQKHSWDGLRSIIHGSRKAPHDFQFVQKTDESGPHSHRLYYLGM
PRENSLLYSEIPKKLLLSWKQMLDHFQATPHHGVYSREEELLRERKRLGV
FGITSYDFHSESGLFLFQASNSLFHCRDGNGFMVSPMKPLEIKTQCSGPR
MDPKICPADPAFFSFINNSDLWVANIETGEERRLTFCHQVLDDPKSAGVA
TFVIQEEFDRFTGYWWCPTASWLKTLRILYEEVDESEVEVIHVPSPALEE
RKTDSYRYPRTGSKNPKIALKLAEFQTDSQGKIVSTQEKELVQPFSSLFP
KVEYIARAGWTRDGKYAWAMFLDRPQQWLQLVLLPPALFIPSTENEEQRL
ASARAVPRNVQPYVVYEEVTNVWINVHDIFYPFPQSDELCFLRANECKTG
FCHLYKVTAVLKSQGYDWSEPFSPGEDEFKCPIKEEIALTSGEWEVLARH
GSKIWVNEETKLVYFQGTKDTPLEHHLYVVSYEAAGEIVRLTTPGFSHSC
SMSQNFDMFVSHYSSVSTPPCVHVYKLSGPDDDPLHKQPRFWASMMEADY
VPPEIFHFHTRSDVRLYGMIYKPHALQPGKKHPTVLFVYGGPQVQLVNNS
FKGIKYLRLNTLASLGYAVVVIDGRGSCQRGLRFEGALKNQMGQVEIEDQ
VEGLQFVAEKYGFIDLSRVAIHGWSYGGFLSLMGLIHKPQVFKVAIAGAP
VTVWMAYDTGYTERYMDVPENNQHGYEAGSVALHVEKLPNEPNRLLILHG
FLDENVHFFHTNFLVSQLIRAGKPYQLQIYPNERHSIRCPESGEHYEVTL
LHFLQEYL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6qzv Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R133 E249 Q648 Y762 Y766 N810 H840
Binding residue
(residue number reindexed from 1)		R97 E207 Q593 Y707 Y711 N755 H785
Enzymatic activity
Catalytic site (original residue number in PDB) Y644 S730 Y731 D808 H840
Catalytic site (residue number reindexed from 1) Y589 S675 Y676 D753 H785
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0043069 negative regulation of programmed cell death
GO:0070269 pyroptotic inflammatory response
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0031252 cell leading edge

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzv, PDBe:6qzv, PDBj:6qzv
PDBsum6qzv
PubMed
UniProtQ86TI2|DPP9_HUMAN Dipeptidyl peptidase 9 (Gene Name=DPP9)

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