Structure of PDB 6qnp Chain C Binding Site BS01

Receptor Information
>6qnp Chain C (length=356) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVI
IDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAH
TMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQ
IINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFA
QFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFF
PPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGET
IFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMA
VRNNLA
Ligand information
>6qnp Chain J (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ASQPLIDLPLIDFCSPVVGQLIDL
Receptor-Ligand Complex Structure
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PDB6qnp Clathrin's adaptor interaction sites are repurposed to stabilize microtubules during mitosis.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R64 P65 I66 S67 L82 K83 A84 Q89 F91 K98 A101 H102 T103 D143 H145 L183 V190 S191 Q192 H229 I231
Binding residue
(residue number reindexed from 1)		R62 P63 I64 S65 L80 K81 A82 Q87 F89 K96 A99 H100 T101 D141 H143 L181 V188 S189 Q190 H227 I229
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005198 structural molecule activity
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030132 clathrin coat of coated pit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qnp, PDBe:6qnp, PDBj:6qnp
PDBsum6qnp
PubMed31932847
UniProtQ00610|CLH1_HUMAN Clathrin heavy chain 1 (Gene Name=CLTC)

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