Structure of PDB 6qcs Chain C Binding Site BS01

Receptor Information
>6qcs Chain C (length=742) Species: 11520 (Influenza B virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRM
KWAMCSNFPLALTKGDMANRIPLEYKGIQLKTNAEDIGTKGQMCSIAAVT
WWNTYGPIGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLL
NPLTKEMPPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTM
ITPIVLAYMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPG
GNKLTESRSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSC
LAAIDGGDVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIG
NGTIQKIGIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDL
IILCMVFSQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFD
QWGYEESPKASELHGINESMNASDYTLKGVVVTRNVIDDFSSTETEKVSI
TKNLSLIKRTGEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQN
TYQWVLKNLVTLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARA
VLKQMRDQEVMKTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENF
IEVRKGSPLFSYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFL
VSGKYDPDLGDFKTIEELEKLKPGEKANILLYQGKPVKVVKR
Ligand information
Receptor-Ligand Complex Structure
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PDB6qcs Structural snapshots of actively transcribing influenza polymerase.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R146 R217 I262 R266 D307 Q325 R326 F327 K341 W359 E363 F406 R425 Y434 R438 S520 S524
Binding residue
(residue number reindexed from 1)		R147 R218 I263 R267 D308 Q326 R327 F328 K342 W360 E364 F407 R426 Y435 R439 S521 S525
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075526 cap snatching
Cellular Component
GO:0033650 host cell mitochondrion
GO:0042025 host cell nucleus
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qcs, PDBe:6qcs, PDBj:6qcs
PDBsum6qcs
PubMed31160782
UniProtQ5V8X3

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