Structure of PDB 6pza Chain C Binding Site BS01

Receptor Information
>6pza Chain C (length=1422) Species: 10034 (Cricetus cricetus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIG
WGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTE
SRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITK
TIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKT
PREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAI
AKLPIAMRALTNYQRLCVAFDAQARKDTQSPQGARAIWRALCHAFGRRLI
LSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQE
FLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIM
HMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWTMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRTTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSAEIRECVQIIGGFFTWTPDGIPTLSNITIRIPRG
QLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSNRSRGPVAYASQKPW
LLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGI
NLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHLSDHLMQAGILELLR
DDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHW
QRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSA
LVLDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRII
LAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALTV
ISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLVSHFAE
TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVCMEYIG
ACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADME
IQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDS
SLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIID
GIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALE
IAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMD
EATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGA
ILEFDKPETLLSQKDSVFASFV
Ligand information
>6pza Chain D (length=19) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLSRKGIIPEEYVLTRLAE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pza Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Resolution3.74 Å
Binding residue
(original residue number in PDB)		R826 S1120 W1297
Binding residue
(residue number reindexed from 1)		R748 S964 W1141
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pza, PDBe:6pza, PDBj:6pza
PDBsum6pza
PubMed31343405
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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