Structure of PDB 6pz9 Chain C Binding Site BS01

Receptor Information
>6pz9 Chain C (length=1177) Species: 10034 (Cricetus cricetus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNLLSKGTYWWMNAFIKTAHKKPIDLRAIAKLPIAMRALTNYQRLCVAFD
AQARKDTQSPQGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCIF
GIVDHLGKEVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGIN
LRGAIQTKIYNKIMHMSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCP
NLWTMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQR
TTLEHSNERLKQTNEMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAF
AVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHIL
VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIRECVQIIGGFFTWTPDG
IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSN
RSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDI
LPHGDQTQIGERGINLSGGQRQRISVARALYQQTNVVFLDDPFSALDVHL
SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTL
KDFQRSECQLFEHWQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVL
VAIDYWLAKWTDSADQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAK
RLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSR
STLLCVSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDT
TQLPLVSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAAN
RWLEVCMEYIGACVVLIAAATSISNSLHLVGLGLTYALMVSNYLNWMVRN
LADMEIQLGAVKRIHALLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLS
VRYDSSLKPVLKHVNTLISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEG
RIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTL
WEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTS
IFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMV
LKRGAILEFDKPETLLSQKDSVFASFV
Ligand information
>6pz9 Chain D (length=19) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLSRKGIIPEEYVLTRLAE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6pz9 Mechanism of pharmacochaperoning in a mammalian K ATP channel revealed by cryo-EM.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		W430 L592 R826 P1117 N1123 C1142 R1145 S1146 Y1294 W1297 N1301
Binding residue
(residue number reindexed from 1)		W194 L356 R512 P722 N728 C747 R750 S751 Y893 W896 N900
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pz9, PDBe:6pz9, PDBj:6pz9
PDBsum6pz9
PubMed31343405
UniProtQ09427|ABCC8_CRICR ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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