Structure of PDB 6oly Chain C Binding Site BS01

Receptor Information

>6oly Chain C (length=318) Species: 145262 (Methanothermobacter thermautotrophicus)

RILLLVLAVIIYGTAGFHFIEGESWTVSLYWTFVTIATVGYGDYSPSTPL
GMYFTVTLIVLGIGTFAVAVERLLEFLINREQMKLIGLIDVAKSRHVVIC
GWSESTLECLRELRGSEVFVLAEDENVRKKVLRSGANFVHGDPTRVSDLE
KANVRGARAVIVDLESDSETIHCILGIRKIDESVRIIAEAERYENIEQLR
MAGADQVISPFVISGRLMSRSIDDGYEAMFVQDVLAEESTRRMVEVPIPE
GSKLEGVSVLDADIHDVTGVIIIGVGRGDELIIDPPRDYSFRAGDIILGI
GKPEEIERLKNYISALVP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6oly Chain C Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6oly Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling.
• Resolution: 3.112 Å
• Binding residue (original residue number in PDB): R241 D244 D245 E248
• Binding residue (residue number reindexed from 1): R220 D223 D224 E227
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0008324 monoatomic cation transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006813 potassium ion transport
• GO:0034220 monoatomic ion transmembrane transport
• GO:0098655 monoatomic cation transmembrane transport

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:6oly, PDBe:6oly, PDBj:6oly
• PDBsum: 6oly
• PubMed: 31772184
• UniProt: O27564|MTHK_METTH Calcium-gated potassium channel MthK (Gene Name=mthK)