Structure of PDB 6n7x Chain C Binding Site BS01

Receptor Information
>6n7x Chain C (length=131) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYFQNLPSRPANKENYTRLLLKHINPNNKYAINPSLPLPHNKLLDDQMG
LLEVSISRSSKMTNQAFLTFVTQEEADRFLEKYTTTALKVQGRKVRMGKA
RTNSLLGLSIEMQKTYNLDIKKVLKARKLKR
Ligand information
>6n7x Chain R (length=308) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaagauaucagaggaaaguccucugaucaaacaugcgcuuccaauaguag
aaggacguuaagcauuuaucauugaacuaguucauugaagucauugaugc
aaacuccuuggucacacacggcgcggaaggcguguuugcugacguuccau
ucccuuguuucaaucauugguuaacugauuuuuggggcccuuuguuucuu
cugccuggagaaguuugacaccaaauauugguguuaggggagcuggggcc
uuucaaaauuuuggaaggucuugguaggaacggguggaucuuauaauuuu
ugauuuau
<<<<<.<<<<<<<<.....>>>>>>>><<<<<<<<<.<<<<<........
<<<<<.<<<..<<<<.<.<<<.<<<<<..>>>>>.>>>.......>>>>>
.>>>>>>>>...............>>>>>>>>>>>>>><<<.<<<<<<..
<<<<<.<<<<<<<..<<<<<<..>>>>>>..>>>>>>>((.......<<<
<<....))>>>>>...<<<<<<<<...>>>>>>>>.>>>>><<<<<<<<<
<<<<<<<<>>>>>>>>>>>>>>>>>.>>>>>>..>>>.>>>>>.......
........
Receptor-Ligand Complex Structure
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PDB6n7x CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y5 Q7 R12 N15 K16 N18 S66 I67 S68 R69 K72 N75 Q76 K100 Q102 G103 R104 K105 R107 R112 T113
Binding residue
(residue number reindexed from 1)		Y3 Q5 R10 N13 K14 N16 S55 I56 S57 R58 K61 N64 Q65 K89 Q91 G92 R93 K94 R96 R101 T102
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0030619 U1 snRNA binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6n7x, PDBe:6n7x, PDBj:6n7x
PDBsum6n7x
PubMed29051543
UniProtP32605|RU1A_YEAST U1 small nuclear ribonucleoprotein A (Gene Name=MUD1)

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