Structure of PDB 6n7h Chain C Binding Site BS01

Receptor Information
>6n7h Chain C (length=174) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CGPGRGFGKRRHPKKLTPLAYKQFIPNVAEKTLGASGRYEGKISRNSERF
KELTPNYNPDIIFKDEENTGADRLMTQRCKDKLNALAISVMNQWPGVKLR
VTEGWDEDGHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWV
YYESKAHIHCSVKAENSVAAKSGG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6n7h Chain C Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6n7h Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		H140 D147 H182
Binding residue
(residue number reindexed from 1)		H117 D124 H159
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:6n7h, PDBe:6n7h, PDBj:6n7h
PDBsum6n7h
PubMed31127104
UniProtQ15465|SHH_HUMAN Sonic hedgehog protein (Gene Name=SHH)

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