Structure of PDB 6n4d Chain C Binding Site BS01

Receptor Information

>6n4d Chain C (length=388) Species: 11309 (unidentified influenza virus)

LEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDHSKCYQ
FALGQGTTLNNKHSNSTIHDRTSHRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDRNATASFVYNGMLVDSIGSWSRNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIREGKIIHISPLSGSAQHIEECSCY
PRYPNVRCVCRDNWKGSNRPVIDINMADYNINSSYVCSGLVGDTPRNDDS
SSSSNCKDPNNERGNPGVKGWAFDNDNDVWMGRTISKDLRSGYETFKVIG
GWTTANSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCVNRCFYVELIRGGP
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

Ligand information

• Ligand ID: BMA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-RWOPYEJCSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-mannopyranose;
  beta-D-mannose;
  D-mannose;
  mannose
• ZINC: ZINC000003830679
• PDB chain: 6n4d Chain H Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6n4d Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): Q391 V392 R394
• Binding residue (residue number reindexed from 1): Q310 V311 R313
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:6n4d, PDBe:6n4d, PDBj:6n4d
• PDBsum: 6n4d
• PubMed: 28934454
• UniProt: A0A0H3YBU9