Structure of PDB 6myo Chain C Binding Site BS01

Receptor Information
>6myo Chain C (length=139) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATTAKEEMARFWEKNTKSSRPLSPHISIYKWSLPMAMSITHRGTGVALSL
GVSLFSLAALLLPEQFPHYVAVVKSLSLSPALIYSAKFALVFPLSYHTWN
GIRHLVWDMGKGFKLSQVEQSGVVVLILTLLSSAAIAAM
Ligand information
Ligand IDFTN
InChIInChI=1S/C17H16F3NO2/c1-11(2)23-13-7-5-6-12(10-13)21-16(22)14-8-3-4-9-15(14)17(18,19)20/h3-11H,1-2H3,(H,21,22)
InChIKeyPTCGDEVVHUXTMP-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.352CC(C)Oc1cccc(NC(=O)c2ccccc2C(F)(F)F)c1
OpenEye OEToolkits 1.7.0CC(C)Oc1cccc(c1)NC(=O)c2ccccc2C(F)(F)F
FormulaC17 H16 F3 N O2
NameN-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide;
flutolanil;
N-(3-Isopropoxy-phenyl)-2-trifluoromethylbenzamide
ChEMBLCHEMBL487185
DrugBank
ZINCZINC000000001479
PDB chain6myo Chain C Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6myo Crystallographic investigation of the ubiquinone binding site of respiratory Complex II and its inhibitors.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		I27 M36 S39 R43
Binding residue
(residue number reindexed from 1)		I26 M35 S38 R42
Annotation score1
Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0009055 electron transfer activity
GO:0046872 metal ion binding
Biological Process
GO:0006099 tricarboxylic acid cycle
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6myo, PDBe:6myo, PDBj:6myo
PDBsum6myo
PubMed34089891
UniProtD0VWW3

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