Structure of PDB 6kon Chain C Binding Site BS01

Receptor Information
>6kon Chain C (length=1092) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAE
RGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKD
MTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVV
SQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFVRIDRKRRQPVT
VLLFSEIMRSTKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFK
EKRYDLARVGRYKVNKKLGLHTEEDVVATIEYLVRLHEGQTTMTVPGGVE
VPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAI
TPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGG
LSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFI
ETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVR
RKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQ
RQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMH
DNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGE
MALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDT
KLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGET
ELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELP
AGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTP
VDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDE
LLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFD
GRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQ
FGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENI
PEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELRLERAAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6kon RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D92 F93 W205 D365 T399 L457 E460 R461 V466
Binding residue
(residue number reindexed from 1)		D72 F73 W185 D309 T343 L401 E404 R405 V410
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6kon, PDBe:6kon, PDBj:6kon
PDBsum6kon
PubMed32127479
UniProtP9WGY9|RPOB_MYCTU DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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