Structure of PDB 6kdo Chain C Binding Site BS01 |
| >6kdo Chain C (length=552) Species: 11676 (Human immunodeficiency virus 1)
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ISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIG
PENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLK
QKKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPM
GWKGSPAIMQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTK
IEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDS
WTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAEL
ELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKT
GKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEAW
WTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRETK
LGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQY
ALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKL
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| PDB | 6kdo Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine. |
| Resolution | 2.573 Å |
Binding residue
(original residue number in PDB) | W24 F61 L74 D76 R78 N81 E89 Q91 I94 G152 P157 Y183 V184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 T473 Q475 Y501 |
Binding residue
(residue number reindexed from 1) | W23 F60 L73 D75 R77 N80 E88 Q90 I93 G151 P156 Y182 V183 D184 M229 G230 N254 Q257 K258 G261 K262 W265 S279 R283 G284 K352 G358 H360 K373 T472 Q474 Y500 |
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