Structure of PDB 6jzo Chain C Binding Site BS01

Receptor Information
>6jzo Chain C (length=663) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFKININ
CIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVEL
LLNHKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVDSLRH
SRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQELSKVENEFKSEYE
ELSRQCKQFAKDLLDQTRSSRELEIILNYRDDLARLKLAIKYRQKEFVAQ
PNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCYLIAPKS
PLGLFIRKPFIKFICHTASYLTFLFLLLLASQHNRQGPPPTIVEWMILPW
VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKY
SNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGR
MLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAF
STLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVV
LLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVII
GRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELKQD
ISSFRFEVLGLLR
Ligand information
Ligand IDY01
InChIInChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1
InChIKeyWLNARFZDISHUGS-MIXBDBMTSA-N
SMILES
SoftwareSMILES
CACTVS 3.352CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O
OpenEye OEToolkits 1.6.1CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C
OpenEye OEToolkits 1.6.1CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCC(=O)O)C)C
CACTVS 3.352CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](CC[C]4(C)[CH]3CC[C]12C)OC(=O)CCC(O)=O
FormulaC31 H50 O4
NameCHOLESTEROL HEMISUCCINATE
ChEMBL
DrugBank
ZINCZINC000058638837
PDB chain6jzo Chain C Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6jzo Structure of the mouse TRPC4 ion channel.
Resolution3.28 Å
Binding residue
(original residue number in PDB)		Y315 F363 L374 L495 F496
Binding residue
(residue number reindexed from 1)		Y262 F310 L321 L434 F435
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6jzo, PDBe:6jzo, PDBj:6jzo
PDBsum6jzo
PubMed
UniProtQ9QUQ5|TRPC4_MOUSE Short transient receptor potential channel 4 (Gene Name=Trpc4)

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