Structure of PDB 6j6g Chain C Binding Site BS01

Receptor Information
>6j6g Chain C (length=920) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHPYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKT
RYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSK
NVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAP
GHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFV
INKLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFAST
KLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFEN
VEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYD
PQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEG
TLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLH
DEDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLY
SVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKY
YPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFS
ESCSNESSRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQNCLDID
GIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDEISPELL
SKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNIDVMKSQI
IPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKKRRGSRI
YKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYFWHKIWR
KVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKGISTGGFMSNDGPT
LEKYISAELYAQLRENGLVP
Ligand information
>6j6g Chain D (length=179) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugug
ggccuuugccuauagaacuuauaacgaacaugguucuugccuuuuaccag
aaccauccggguguugucuccauagaaacagguaaagcuguccguuacug
ugggcuugccauauuuuuuggaacuuuuc
...<<<<<.<<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<
<<<....>>>>>>>>..............<<<<<<<<...........>>
>>>>>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>
>>>>>.>>.....................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6j6g Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R97 K99 L100 Q101 F106 T107 Q108 L109 N112 R160 D163 K166 K173 R405
Binding residue
(residue number reindexed from 1)		R31 K33 L34 Q35 F40 T41 Q42 L43 N46 R94 D97 K100 K107 R339
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000387 spliceosomal snRNP assembly
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j6g, PDBe:6j6g, PDBj:6j6g
PDBsum6j6g
PubMed30879786
UniProtP36048|SN114_YEAST Pre-mRNA-splicing factor SNU114 (Gene Name=SNU114)

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