Structure of PDB 6iwa Chain C Binding Site BS01
Receptor Information
>6iwa Chain C (length=427) Species:
10090
(Mus musculus) [
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QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS
Ligand information
>6iwa Chain A (length=28) Species:
9606
(Homo sapiens) [
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AKKKLREYQQRNSPGVPTGAKKKKKIKN
Receptor-Ligand Complex Structure
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PDB
6iwa
Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
S105 R106 F138 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 N239 W273 Y277 D280 G281 R315 N319 T322 G323 K353 W357 N361 E396 W399 D433
Binding residue
(residue number reindexed from 1)
S35 R36 F68 W72 N76 S79 G80 T85 Q111 W114 N118 G121 D122 W161 R168 N169 W203 Y207 D210 G211 R245 N249 T252 G253 K283 W287 N291 E326 W329 D363
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6iwa
,
PDBe:6iwa
,
PDBj:6iwa
PDBsum
6iwa
PubMed
31541088
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
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