Structure of PDB 6iw8 Chain C Binding Site BS01
Receptor Information
>6iw8 Chain C (length=419) Species:
10090
(Mus musculus) [
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WSVEDIVKGINSNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVS
FLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHA
HISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACGYL
RNLTWTLSNLCRNNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISY
LTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTDEQ
TQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHG
LVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEPLMN
LLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQ
RHNESVYKASLNLIEKYFS
Ligand information
>6iw8 Chain A (length=28) Species:
9606
(Homo sapiens) [
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AKKKLREYQQRNSPGVPTGAKKKKKIKN
Receptor-Ligand Complex Structure
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PDB
6iw8
Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha.
Resolution
2.8 Å
Binding residue
(original residue number in PDB)
W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 W273 D280 G281 R315 V321 T322 G323 E354 W357 N361 K392 E396
Binding residue
(residue number reindexed from 1)
W66 N70 S73 G74 T79 Q105 W108 N112 D116 W155 R162 W196 D203 G204 R238 V244 T245 G246 E277 W280 N284 K315 E319
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6iw8
,
PDBe:6iw8
,
PDBj:6iw8
PDBsum
6iw8
PubMed
31541088
UniProt
P52293
|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)
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