Structure of PDB 6ik9 Chain C Binding Site BS01 |
| >6ik9 Chain C (length=553) Species: 11676 (Human immunodeficiency virus 1)
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PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKI
GPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGL
KQKKSVTVLDVSAAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLP
MGWKGSPALLQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRT
KIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKD
SWTVNDIQKLVGKLNWASQIYAGIKVRQLSKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLK
TGKYARMKGAHTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA
WWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIIGAETFYVDGAANRET
KLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGLEVNIVTDSQ
YALGIIQAQPDKSESELVSQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDK
LVS |
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| PDB | 6ik9 Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors. |
| Resolution | 2.435 Å |
Binding residue
(original residue number in PDB) | W24 F61 L74 D76 R78 N81 E89 Q91 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 T473 Q475 K476 Y501 |
Binding residue
(residue number reindexed from 1) | W24 F61 L74 D76 R78 N81 E89 Q91 I94 G152 P157 Y183 M184 D185 M230 G231 N255 Q258 K259 G262 K263 W266 S280 R284 G285 K353 G359 H361 K374 T473 Q475 K476 Y501 |
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| Enzyme Commision number |
3.1.26.13: retroviral ribonuclease H. |
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