Structure of PDB 6ijr Chain C Binding Site BS01

Receptor Information

>6ijr Chain C (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDK
SPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQ
EITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEG
QGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILS
GDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQ
IVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

Ligand information

>6ijr Chain D (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

HKILHRLLQE

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6ijr Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPAR gamma phosphorylation.
Resolution	2.85 Å
Binding residue (original residue number in PDB)	K301 Q314 V315 L318 K319 E471
Binding residue (residue number reindexed from 1)	K107 Q120 V121 L124 K125 E277

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0004879	nuclear receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6ijr, PDBe:6ijr, PDBj:6ijr
PDBsum	6ijr
PubMed	31371757
UniProt	P37231\|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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