Structure of PDB 6hyu Chain C Binding Site BS01

Receptor Information
>6hyu Chain C (length=585) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAEAGYTSRGKIGCTQ
PRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLL
RECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRQDMKLIVTS
ATLDAVKFSQYFYEAPIFTIPGTYPVEILYTKDASLITVMQIHLTEPPGD
ILVFLTGQEEIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIF
DPAPPGSRKVVIATNIAETLTIDGIYYVVDPGFVKQKVVQAQAKQRAGRA
GRTGPGKCYRLYTERAYRDEMLTPEIQRTNLASTVLSLKAMGINDLLPME
TLITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCS
EEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSW
KNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVR
VQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYH
ELVLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6hyu Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
Resolution3.22 Å
Binding residue
(original residue number in PDB)		Q783 K861 K863
Binding residue
(residue number reindexed from 1)		Q208 K285 K287
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome

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Molecular Function
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Biological Process
External links
PDB RCSB:6hyu, PDBe:6hyu, PDBj:6hyu
PDBsum6hyu
PubMed31409651
UniProtQ14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 (Gene Name=DHX8)

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