Structure of PDB 6hom Chain C Binding Site BS01

Receptor Information
>6hom Chain C (length=271) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMLEREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIA
ALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAH
IPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEII
PLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILG
KMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQ
VLKDDTTTKRWLAQLVKNLQE
Ligand information
>6hom Chain D (length=26) Species: 7227 (Drosophila melanogaster) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
DDDLGFDPFVETQKGLAELMENEVVQ
Receptor-Ligand Complex Structure
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PDB6hom A conserved CAF40-binding motif in metazoan NOT4 mediates association with the CCR4-NOT complex.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		R46 T83 A84 H85 N88 C91 N92 A95 R130 P131 Y134 L137 T138 K148 L177 V181 F184 Q187 K188 R227 H231 W275
Binding residue
(residue number reindexed from 1)		R32 T69 A70 H71 N74 C77 N78 A81 R116 P117 Y120 L123 T124 K134 L163 V167 F170 Q173 K174 R213 H217 W261
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006402 mRNA catabolic process
Cellular Component
GO:0030014 CCR4-NOT complex

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Biological Process
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Cellular Component
External links
PDB RCSB:6hom, PDBe:6hom, PDBj:6hom
PDBsum6hom
PubMed30692204
UniProtQ92600|CNOT9_HUMAN CCR4-NOT transcription complex subunit 9 (Gene Name=CNOT9)

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