Structure of PDB 6h0f Chain C Binding Site BS01

Receptor Information
>6h0f Chain C (length=32) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGRGERPFQCNQCGASFTQKGNLLRHIKLHSG
Ligand information
Ligand IDY70
InChIInChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)/t8-/m0/s1
InChIKeyUVSMNLNDYGZFPF-QMMMGPOBSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C1NC(=O)CCC1N3C(=O)c2cccc(c2C3=O)N
CACTVS 3.385Nc1cccc2C(=O)N([C@H]3CCC(=O)NC3=O)C(=O)c12
OpenEye OEToolkits 1.9.2c1cc2c(c(c1)N)C(=O)N(C2=O)[C@H]3CCC(=O)NC3=O
CACTVS 3.385Nc1cccc2C(=O)N([CH]3CCC(=O)NC3=O)C(=O)c12
OpenEye OEToolkits 1.9.2c1cc2c(c(c1)N)C(=O)N(C2=O)C3CCC(=O)NC3=O
FormulaC13 H11 N3 O4
NameS-Pomalidomide
ChEMBLCHEMBL2093113
DrugBank
ZINCZINC000003940470
PDB chain6h0f Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6h0f Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Q146 C147 N148 C150 G151
Binding residue
(residue number reindexed from 1)		Q9 C10 N11 C13 G14
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6h0f, PDBe:6h0f, PDBj:6h0f
PDBsum6h0f
PubMed30385546
UniProtQ13422|IKZF1_HUMAN DNA-binding protein Ikaros (Gene Name=IKZF1)

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