Structure of PDB 6fvo Chain C Binding Site BS01

Receptor Information

>6fvo Chain C (length=389) Species: 83331 (Mycobacterium tuberculosis CDC1551)

VGLTDLTFRLLRESFADAVSWVAKNLPARPAVPVLSGVLLTGSDNGLTIS
GFDYEVSAEAQVGAEIVSPGSVLVSGRLLSDITRALPNKPVDVHVEGNRV
ALTCGNARFSLPTMPVEDYPTLPTLPEETGLLPAELFAEAISQVAIAAGR
DDTLPMLTGIRVEILGETVVLAATDRFRLAVRELKWSASSPDIEAAVLVP
AKTLAEAAKAGIGGSDVRLSLGTGPGGKDGLLGISGNGKRSTTRLLDAEF
PKFRQLLPTEHTAVATMDVAELIEAIKLVALVADRGAQVRMEFADGSVRL
SAGADDVGRAEEDLVVDYAGEPLTIAFNPTYLTDGLSSLRSERVSFGFTT
AGKSALLRPVSGDDRPNGNGPFPAVSTDYVYLLMPVRLP

Ligand information

>6fvo Chain J (length=5) Species: 32630 (synthetic construct)

QFDLF

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6fvo Peptide Interactions on Bacterial Sliding Clamps.
• Resolution: 2.689 Å
• Binding residue (original residue number in PDB): T181 R183 F184 R185 L186 M396 P397 V398 R399
• Binding residue (residue number reindexed from 1): T174 R176 F177 R178 L179 M384 P385 V386 R387

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0008408 3'-5' exonuclease activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006260 DNA replication
• GO:0006271 DNA strand elongation involved in DNA replication
• GO:0046677 response to antibiotic
• GO:0071897 DNA biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005737 cytoplasm
• GO:0009274 peptidoglycan-based cell wall
• GO:0009360 DNA polymerase III complex

External links

• PDB: RCSB:6fvo, PDBe:6fvo, PDBj:6fvo
• PDBsum: 6fvo
• PubMed: 30912430
• UniProt: P9WNU1|DPO3B_MYCTU Beta sliding clamp (Gene Name=dnaN)