Structure of PDB 6fqv Chain C Binding Site BS01

Receptor Information
>6fqv Chain C (length=473) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMT
PDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGN
FGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSV
LPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAEL
MEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVRIVVTEIPFQV
NKARMIEKIAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVIL
NNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQ
YNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLS
EKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQL
VRDELTEIRDRFGDDRRTEIQLG
Ligand information
Receptor-Ligand Complex Structure
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PDB6fqv A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Y25 R122 Y123 I175 A176 G178 M179 R238
Binding residue
(residue number reindexed from 1)		Y16 R113 Y114 I166 A167 G169 M170 R229
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:6fqv, PDBe:6fqv, PDBj:6fqv
PDBsum6fqv
PubMed29538767
UniProtQ99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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