Structure of PDB 6fj5 Chain C Binding Site BS01

Receptor Information

>6fj5 Chain C (length=199) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPV
QLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQH
LIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCM
GGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKK

Ligand information

>6fj5 Chain F (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

aggcatgcctaggcatgcct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6fj5 New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Resolution	2.051 Å
Binding residue (original residue number in PDB)	K120 R248
Binding residue (residue number reindexed from 1)	K27 R155

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:6fj5, PDBe:6fj5, PDBj:6fj5
PDBsum	6fj5
PubMed	30057026
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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