Structure of PDB 6fhh Chain C Binding Site BS01

Receptor Information

>6fhh Chain C (length=725) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGG
EAENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEIL
RSNPTDEQAVNICKAALGIRINNSFSFGGYNFKRVKGSSQRTEKAVLTGN
LQTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLM
ITLMVFSQEEKMLKAVRGDLNFNPMYQLLRHFQKDSSTLLKNWGTEEIDP
IMGIAGIMPDGTINKTQTLMGVRLSQIRVNIDKYLRVRNEKGELLISPEE
VSEAQGQEKLPINYNSSLMWEVNGPESILTNTYHWIIKNWELLKTQWMTD
PTVLYNRIEFEPFQTLIPKGNRAIYSGFTRTLFQQMRDVEGTFDSIQIIK
LLPFSAHPPSLGRTQFSSFTLNIRGAPLRLLIRGNSQVFNYNQMENVIIV
LGKSVGSPERSILTESSSIESAVLRGFLILGKANSKYGPVLTIGELDKLG
RGEKANVLIGQGDTVLVMKRKRDSS

Ligand information

>6fhh Chain R (length=13)

uauaccucugcuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6fhh Towards New Anti-Influenza Therapeutics: Structure-Activity Relationships in the Interaction between Heterotrimeric Influenza Polymerase and Pol II C-terminal domain
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): S36 G37 R38 E40 R46 W49
• Binding residue (residue number reindexed from 1): S38 G39 R40 E42 R48 W51

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:6fhh, PDBe:6fhh, PDBj:6fhh
• PDBsum: 6fhh
• UniProt: H6QM90