Structure of PDB 6exn Chain C Binding Site BS01

Receptor Information
>6exn Chain C (length=880) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PYGKEVEVLMETKNTQSPQTPLVEPVTERTKLQEHTIFTQLKKNIPKTRY
NRDYMLSMANIPERIINVGVIGPLHSGKTSLMDLLVIDSHKRIPDMSKNV
ELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCTDLESKSRMINFLDAPGH
VNFMDETAVALAASDLVLIVIDVVEGVTFVVEQLIKQSIKNNVAMCFVIN
KLDRLILDLKLPPMDAYLKLNHIIANINSFTKGNVFSPIDNNIIFASTKL
GFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGSVYYHKGNFRTKPFENVE
KYPTFVEFILIPLYKIFSYALSMEKDKLKNLLRSNFRVNLSQEALQYDPQ
PFLKHVLQLIFRQQTGLVDAITRCYQPFELFDNKTAHLSIPGKSTPEGTL
WAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRILDTSQSESRQKRQLHET
PSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSAYIKSATLYSVKSKE
DMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLDALNKISKYYPGVII
KVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKISDPLTVFSESCSNE
SFASIPVSNISVAAEPMDSKMIQDLSRNTNPRKLSKILRTEYGWDSLASR
NVWSFYNGNVLINDSPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYK
LLSISVPVMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPI
VEELMKKRRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGL
GMCQLYFWHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKG
ISTGGFMSNDGPTLEKYISAELYAQLRENG
Ligand information
>6exn Chain 5 (length=171) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugug
ggccuuuuauugccuauagaacuuauaacgaacaugguucuugccuuuua
ccagaaccauccggguguugucuccauaaacagguaaagcuguccguuac
ugugggcuugccauuuuuugg
..<<<<<<.<<<<<.......<<<<..<<<<<.<<<<<<<.....<<<<<
<<<........>>>>>>>>..............<<<<<<<<.........
..>>>>>>>>...>>>>>>>>>>>>....<<<<......>>>>>>>>..>
>>>>>>>.>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6exn Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		R97 K99 Q101 I105 T107 Q108 L109 K110 N112 R160 P162 D163 K166 N167 I185 H334
Binding residue
(residue number reindexed from 1)		R29 K31 Q33 I37 T39 Q40 L41 K42 N44 R92 P94 D95 K98 N99 I117 H266
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000387 spliceosomal snRNP assembly
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6exn, PDBe:6exn, PDBj:6exn
PDBsum6exn
PubMed29146871
UniProtP36048|SN114_YEAST Pre-mRNA-splicing factor SNU114 (Gene Name=SNU114)

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