Structure of PDB 6evk Chain C Binding Site BS01

Receptor Information

>6evk Chain C (length=727) Species: 1129347 (Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10)))

SGMERIKELMEMVKNSRMREILTTTSVDHMAVIKKYTSGRQEKNPALRMK
WMMAMKYPISASSRIREMIPEKDEDGNTLWTNTKDAGSNRVLVSPNAVTW
WNRAGPVSDVVHYPRVYKMYFDRLERLTHGTFGPVKFYNQVKVRKRVDIN
PGHKDLTSREAQEVIMEVVFPNEVGARTLSSDAQLTITKEKKEELKNCKI
SPIMVAYMLERELVRRTRFLPIAGATSSTYVEVLHLTQGTCWEQQYTPGG
EAENDDLDQTLIIASRNIVRRSIVAIDPLASLLSMCHTTSISSEPLVEIL
RSNPTDEQAVNICKAALGIRINSFSFGGYNFKRVKGSSQRTEKAVLTGNL
QTLTMTIFEGYEEFNVSGKRASAVLKKGAQRLIQAIIGGRTLEDILNLMI
TLMVFSQEEKMLKAVRGDLNFVNQRLNPMYQLLRHFQKDSSTLLKNWGTE
EIDPIMGIAGIMPDGTINKTQTLMGVRLSQRVNIDKYLRVRNEKGELLIS
PEEVSEAQGQEKLPINYNSSLMWEVNGPESILTNTYHWIIKNWELLKTQW
MTDPTVLYNRIEFEPFQTLIPKGNRAIYSGFTRTLFQQMRDVEGTFDSIQ
IIKLLPFSAHPPSLGRTQFSSFTLNIRGAPLRLLIRGNSQVFNYNQMENV
IIVLGKSVGSPERSILTESSSIESAVLRGFLILGKANSKYGPVLTIGELD
KLGRGEKANVLIGQGDTVLVMKRKRDS

Ligand information

>6evk Chain R (length=13)

uauaccucugcuu

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6evk Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): G37 R38 E40 R46 W49
• Binding residue (residue number reindexed from 1): G39 R40 E42 R48 W51

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006370 7-methylguanosine mRNA capping
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0075526 cap snatching

Cellular Component

• GO:0033650 host cell mitochondrion
• GO:0042025 host cell nucleus
• GO:0044423 virion component

External links

• PDB: RCSB:6evk, PDBe:6evk, PDBj:6evk
• PDBsum: 6evk
• PubMed: 29202182
• UniProt: H6QM90