Structure of PDB 6czo Chain C Binding Site BS01

Receptor Information
>6czo Chain C (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
Ligand information
>6czo Chain D (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HSSILKPPSRRVSFADTIKV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6czo KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		Q49 E54 L55 E56 N86 E116 N117 F119 D166 D242 F257 L289 M290 C291
Binding residue
(residue number reindexed from 1)		Q44 E49 L50 E51 N81 E111 N112 F114 D161 D237 F252 L284 M285 C286
Enzymatic activity
Catalytic site (original residue number in PDB) D64 H66 D92 D95 R96 N124 H125 H173 R221 H248
Catalytic site (residue number reindexed from 1) D59 H61 D87 D90 R91 N119 H120 H168 R216 H243
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6czo, PDBe:6czo, PDBj:6czo
PDBsum6czo
PubMed30100357
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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