Structure of PDB 6cpm Chain C Binding Site BS01

Receptor Information
>6cpm Chain C (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLNDKYQEEL
NFDNPLGMRGEIAKSYAELIKQMWSGKFSYVTPRAFKTQVGRFAPQFSGQ
DCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLKR
NDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMPKKPFVKLK
DCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFS
YSRYMRDKLDTLVDFPINDLDMSGCRYNLIAVSNHYGGMGGGHYTAFAKN
KDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQDSSG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6cpm Chain C Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6cpm Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15.
Resolution2.011 Å
Binding residue
(original residue number in PDB)		D548 Q614
Binding residue
(residue number reindexed from 1)		D269 Q335
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:6cpm, PDBe:6cpm, PDBj:6cpm
PDBsum6cpm
PubMed30713027
UniProtQ9Y4E8|UBP15_HUMAN Ubiquitin carboxyl-terminal hydrolase 15 (Gene Name=USP15)

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