Structure of PDB 6ccv Chain C Binding Site BS01

Receptor Information
>6ccv Chain C (length=1099) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGE
ENPVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTY
AAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQL
VRSPGVYFDETIDKSTEKTLHSVKVIPGRGAWLEFVRIDRKRRQPVTVLL
KALGWTNEQIVERFGFSEIMMGTLEKDTTSGTDEALLDIYRKLRPGEPPT
KESAQTLLENLFFKEKRYDLARVGRYKVNKKLTLTEEDVVATIEYLVRLH
EGQTSMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQIRVGLSRMERV
VRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGL
THKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGS
LSVYARVNPFGFIETPYRKVENGVVTDQIDYLTADEEDRHVVAQANSPTD
ENGRFTEDRVMVRKKGGEVEFVSADQVDYMDVSPRQMVSVATAMIPFLEH
DDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVADKTGV
IEEVSADYITVMADDGTRQSYRLRKFARSNHGTCANQRPIVDAGQRVEAG
QVIADGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTS
IHIEEHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDG
DILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIG
IRVFSREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKIL
PVEDMPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKAGWNIDVA
AGVPDWASKLPEELYSAPADSTVATPVFDGAQEGELAGLLGSTLPNRDGE
VMVDADGKSTLFDGRSGEPFPYPVTVGYMYILKLHHLVDDKIHARSTGPY
SMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGR
VKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMR
Ligand information
>6ccv Chain G (length=17) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ccv Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		L266 E276 P277 P278
Binding residue
(residue number reindexed from 1)		L237 E247 P248 P249
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ccv, PDBe:6ccv, PDBj:6ccv
PDBsum6ccv
PubMed30297823
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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