Structure of PDB 6cce Chain C Binding Site BS01

Receptor Information
>6cce Chain C (length=1095) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGE
ENPVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTY
AAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQL
VRSPGVYFDETIDKSTEKTLHSVKVIPGRGAWLEFVRIDRKRRQPVTVLL
KALEQIVERFGFSEIMMGTLEKDTTSGTDEALLDIYRKLRPGEPPTKESA
QTLLENLFFKEKRYDLARVGRYKVNKKLTLTEEDVVATIEYLVRLHEGQT
SMTVPGGVEVPVEVDDIDHFGNRRLRTVGELIQNQIRVGLSRMERVVRER
MTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKR
RLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVY
ARVNPFGFIETPYRKVENGVVTDQIDYLTADEEDRHVVAQANSPTDENGR
FTEDRVMVRKKGGEVEFVSADQVDYMDVSPRQMVSVATAMIPFLEHDDAN
RALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVADKTGVIEEV
SADYITVMADDGTRQSYRLRKFARSNHGTCANQRPIVDAGQRVEAGQVIA
DGPCTQNGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIE
EHEIDARDTKLGAEEITRDIPNVSDEVLADLDERGIVRIGAEVRDGDILV
GKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVF
SREDDDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVED
MPFLPDGTPVDIILNTHGVPRRMNIGQILETHLGWVAKAGWNIDVAAGVP
DWASKLPEELYSAPADSTVATPVFDGAQEGELAGLLGSTLPNRDGEVMVD
ADGKSTLFDGRSGEPFPYPVTVGYMYILKLHHLVDDKIHARSTGPYSMIT
QQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVY
EAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIEMR
Ligand information
>6cce Chain G (length=19) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
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PDB6cce Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		L266 G275 E276 P277 P278
Binding residue
(residue number reindexed from 1)		L233 G242 E243 P244 P245
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6cce, PDBe:6cce, PDBj:6cce
PDBsum6cce
PubMed30297823
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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