Structure of PDB 6be6 Chain C Binding Site BS01

Receptor Information
>6be6 Chain C (length=433) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEKNTCQLYIQTDHLFFKYYGTREAVIAQISSHVKAIDTIYQTTDFSGIR
QISFMVKRIRINTTADEKDPTNPFRFPNIGVEKFLELNSEQNHDDYCLAY
VFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNTGIITVQ
NYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYI
MYARATSGDKLNNNKFSLCSIRQISQVLEKKRNNCFVESGQPICGNGMVE
QGEECDCGYSDQCKDECCFDANQPEGRKCKLKPGKQCSPSQGPCCTAQCA
FKSKSEKCRDDSDCAREGICNGFTALCPASDPKPQFTDCNRHTQVCINGQ
CAGSICEKYGLEECTCADKELCHVCCMKKMDPSTCASTGSVQWSRHFSGR
TITLQPGSPCNDFRGYCDVFMRCRLVDADGPLG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6be6 Chain C Residue 706 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6be6 Structural Basis for Regulated Proteolysis by the alpha-Secretase ADAM10.
Resolution2.8 Å
Binding residue
(original residue number in PDB)
H383 H387 H393
Binding residue
(residue number reindexed from 1)
H167 H171 H177
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.81: ADAM10 endopeptidase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function

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Biological Process
External links
PDB RCSB:6be6, PDBe:6be6, PDBj:6be6
PDBsum6be6
PubMed29224781
UniProtO14672|ADA10_HUMAN Disintegrin and metalloproteinase domain-containing protein 10 (Gene Name=ADAM10)

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