Structure of PDB 6b8o Chain C Binding Site BS01

Receptor Information
>6b8o Chain C (length=107) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGPCQRVVSTHNLWLLS
FLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRK
VLVEVLA
Ligand information
Ligand IDPSF
InChIInChI=1S/C18H34NO10P/c1-3-5-7-9-16(20)26-11-14(29-17(21)10-8-6-4-2)12-27-30(24,25)28-13-15(19)18(22)23/h14-15H,3-13,19H2,1-2H3,(H,22,23)(H,24,25)/t14-,15+/m1/s1
InChIKeyMIQYPPGTNIFAPO-CABCVRRESA-N
SMILES
SoftwareSMILES
CACTVS 3.341CCCCCC(=O)OC[C@H](CO[P@](O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCC
OpenEye OEToolkits 1.5.0CCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)OC(=O)CCCCC
CACTVS 3.341CCCCCC(=O)OC[CH](CO[P](O)(=O)OC[CH](N)C(O)=O)OC(=O)CCCCC
OpenEye OEToolkits 1.5.0CCCCCC(=O)OCC(CO[P@@](=O)(O)OC[C@@H](C(=O)O)N)OC(=O)CCCCC
ACDLabs 10.04O=C(OC(COP(=O)(OCC(C(=O)O)N)O)COC(=O)CCCCC)CCCCC
FormulaC18 H34 N O10 P
Name1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE;
PHOSPHATIDYLSERINE
ChEMBL
DrugBank
ZINC
PDB chain6b8o Chain C Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6b8o Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H67 N68
Binding residue
(residue number reindexed from 1)		H44 N45
Annotation score1
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6b8o, PDBe:6b8o, PDBj:6b8o
PDBsum6b8o
PubMed29794134
UniProtQ9NZC2|TREM2_HUMAN Triggering receptor expressed on myeloid cells 2 (Gene Name=TREM2)

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