Structure of PDB 6az1 Chain C Binding Site BS01

Receptor Information
>6az1 Chain C (length=212) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPLSKKRMIIRDGVFYAELFEFLKRELAEEGFSGVSYHVTTLRTEIVIKA
TKTREVLGVNGRRIRELTACIQQRFNYKEGKLQLYVERVEVRGLSAMAQV
ESLRFKLLSNLQVRRAAMGIIRYVMESGAKGCEVTVGGKIKGQRAKSMTF
RDGYMIKSGTAHKSFVDSACRHCYMRAGCIGVKVKIMLPGDSTGRNGPSE
PLPDVITVIEPK
Ligand information
>6az1 Chain 1 (length=1760) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcagcaggaaucugcgcauggcucauuaca
ucagacguaaucugccgcaaaaaucuugcgguccgcaaaauuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaccgggugucuccagagacg
cccagcgaaugaaugacaaaaccaaugccugcaguaacacccagcagugu
ugacucaauucauuccgugcgaaagccggcccggcgucuuuugacgaaca
acugcccuaucagcuggugauggccguguaguggacugccauggcguuga
cgggagcgggggauuaggguucgauuccggagagggagccugagaaauag
cuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucaaaa
caaaacgaugaggcagcgaaaagaaauagaguuuucaaugggggauauuu
aaacccauccaauaucgaguaacaauuggaggacaagucuggugccagca
cccgcgguaauuccagcuccaaaagcguauauuaaugcuguugcuguuaa
aggguucguaguugaacugugggcuguucccguccauucggaugacccug
cagcccgugaacagaaacaacgggagugggggcguccgugauuuuuuacu
gugacuaaagaagcgugacuaaagcagucaugacugaauuagaaagcaug
ggauaacaaaggagcaguuuuaaaggucuauuggagauuauggagcugug
cgacaagugcuuucccauaggaaugaaggaggguagucgggggagaacgu
acuggggcgucagaggugaaauucuuagaccgcaccaagacgaacuacag
cgaaggcauucuucaaggauaccuuccucaaucaagaaccaaagugugga
gaucgaagaugauuagagaccauuguaguccacacugcaaacgaugacac
ccaugaauuggggauccuuacguaucuuucucagcacguuuucuguuuuc
acgcgaaagcuuugagguuacagucucaggggggaguacguucgcaagag
ugaaacuuaaagaaauugacggaauggcaccacaagacguggagcgugcg
guuuaauuugacucaacacggggaacuuuaccagauccggacaggaugag
gauugacagauugaguguucuuucucgauucccugaaugguggugcaugg
ccgcuuuuggucgguggagugauuuguuugguugauuccgucaacggacg
agauccaagcugcccaguagaauucagaauugcccauaggauaggcauuc
gucgaauucuucucugcgggauuccuuguaaugcacaaggugaaauuuug
ggcaacagcaggucugugaugcuccucaauguucugggcgacacgcgcac
uacaaugucagugagaacaagaaaaacgagucgaaccuacuugaucaaaa
gaguggggaaaccccggaaucacauagacucacuugggaccgaggauugc
aauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaaac
ugugccgauuacgucccugccauuuguacacaccgcccgucguuguuucc
gaugauggugcaauacaggugaucggacgaaaguucaccgauauuucuuc
aauagaggaagcaaaagucguaacaagguagcuguaggugaaccugcagc
uggaucauuu
...<<<<<.{.((((>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<<.>>>>...>>.>>......<<..<....
.<<<..<<..<<...<<.<<.....<<<<<<.>>>>>>...<<.....<<
<<<<.....>>>>>>......>>..........<<<<<<<<<..>>>>>>
>>>.<<<<<<<<<<.....((.{....<..>...................
.......>>>>>>>>...>>....<<<<<.>>>>>...>>.>>..>>>>.
.>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>.....
.>>>..<<<<<<<<....>>>>...>>>>>>>.<<.<<<..........>
>>.>>.<<<<....>>>>...>>>>>>.........<<<....<<<....
......>>>..>>>..>....>>>....<<<..>>>.....<<<<.....
.......>>>.....>.........<<<<<((....<.<<<<.....<<.
.))>>.......>>>>>>>>>>..>>>>>>>>>>.........<<<[[..
...<<<<...<<<..<....<...<<.<<....<......>..>>...>>
...>.........................................<<<<<
<<<.......<<...<.......>..<<<..>>>....>>......>>>>
>..>>>..........<<<.<..<<...<......}.))...>..>>..>
.>>>...................>......<<<<<.<<...<<<<<<<<.
.<<<<.<<<...<<<......>>>......>>>.>>>.>.>>.......<
<....>>.>>>>>>...>>>>>.>>....>>>...>>>>...<<<<<<<<
...<...<<<<.<.....>.>>>>...>>>>>>>>>.........<<<.<
<...<..<.<<<<<..........<.<......>.>..>>>>>.>..>..
..<<..]]>>.....>>.....>>>.>>>.<<<......<<<<....>>>
>....>>>..)))).}<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<
<<......<<........>>..........<<<<<......<<<<.....
....<<.<<<........>>>.>>.......>>>>...<<.<<<..<<.<
<<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>.
...<<<<<.<<<<.....<<<<<<<.<<<<................>>>>
...>>>>>>>.....>>>>....<<<<<<.....>>>>>>.......>>>
>>....>>>.>>>.....>>>>>>>.......>>>>>...>>.>>>>>.>
>.....<<<.<<<.......<.....<<<.>>>..<<<<<<<........
>>>>>>>....>........>>>...>>>......<....<<<..<....
......>..>>>.....>.....>>>>>>....<<<<<<<.........>
>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<<<
..<<.<<<.<.<<<<..<<<<<.<........>.>>>>>..>>>>.>.>>
>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<<..>>>>>>>>>
>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6az1 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		P3 L4 S5 K6 K7 R8 N77 K79 G138 K140 Q144 R145 A146 R152 Y155 M156 K158 S159 G160 T161 H173 Y175 A178 G179 C180 G182 K184 P204 D205
Binding residue
(residue number reindexed from 1)		P2 L3 S4 K5 K6 R7 N76 K78 G137 K139 Q143 R144 A145 R151 Y154 M155 K157 S158 G159 T160 H172 Y174 A177 G178 C179 G181 K183 P203 D204
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0015935 small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6az1, PDBe:6az1, PDBj:6az1
PDBsum6az1
PubMed29150609
UniProtE9BQ25

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