Structure of PDB 6atk Chain C Binding Site BS01

Receptor Information
>6atk Chain C (length=891) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEAT
DVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLK
GSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADA
RKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVT
EFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYA
LNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSL
LFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYV
EYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQ
ISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNL
WDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFL
LDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGN
EWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFN
LASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGP
MKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPE
CEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFR
NATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISIT
NNVIGQGLVWDFVQSNWKKLFNSNLIQAVTRRFSTEYELQQLEQFKKDNE
ETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
Ligand information
>6atk Chain F (length=11) Species: 11137 (Human coronavirus 229E) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PQSGGGKCFNC
Receptor-Ligand Complex Structure
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PDB6atk Receptor-binding loops in alphacoronavirus adaptation and evolution.
Resolution3.505 Å
Binding residue
(original residue number in PDB)		T244 E286 D288 Y289 V290 E291
Binding residue
(residue number reindexed from 1)		T177 E219 D221 Y222 V223 E224
Enzymatic activity
Catalytic site (original residue number in PDB) E355 H388 E389 H392 E411 S469 Y477
Catalytic site (residue number reindexed from 1) E288 H321 E322 H325 E344 S402 Y410
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0038023 signaling receptor activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0043171 peptide catabolic process
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0030667 secretory granule membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6atk, PDBe:6atk, PDBj:6atk
PDBsum6atk
PubMed29170370
UniProtP15144|AMPN_HUMAN Aminopeptidase N (Gene Name=ANPEP)

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