Structure of PDB 6ako Chain C Binding Site BS01

Receptor Information
>6ako Chain C (length=97) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNS
IRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ako Structural basis for DNA recognition by FOXC2.
Resolution2.396 Å
Binding residue
(original residue number in PDB)		K72 S76 Y77 I78 N118 S119 H122 R164
Binding residue
(residue number reindexed from 1)		K3 S7 Y8 I9 N49 S50 H53 R95
Binding affinityPDBbind-CN: Kd=0.79uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6ako, PDBe:6ako, PDBj:6ako
PDBsum6ako
PubMed30722065
UniProtQ99958|FOXC2_HUMAN Forkhead box protein C2 (Gene Name=FOXC2)

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