Structure of PDB 5zwo Chain C Binding Site BS01

Receptor Information
>5zwo Chain C (length=843) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHTIFTQLKKNIPKTRYNRDYMLSMANIPERIINVGVIGPLHSGKTSLMD
LLVIDSHKRIPDMSKNVELGWKPLRYLDNLKQEIDRGLSIKLNGSTLLCT
DLESKSRMINFLDAPGHVNFMDETAVALAASDLVLIVIDVVEGVTFVVEQ
LIKQSIKNNVAMCFVINKLDRLILDLKLPPMDAYLKLNHIIANINSFTKG
NVFSPIDNNIIFASTKLGFTFTIKEFVSYYYAHSIPSSKIDDFTTRLWGS
VYYHKGNFRTKPFENVEKYPTFVEFILIPLYKIFSYALSMEKDKLKNLLR
SNFRVNLSQEALQYDPQPFLKHVLQLIFRQQTGLVDAITRCYQPFELFDN
KTAHLSIPGKSTPEGTLWAHVLKTVDYGGAEWSLVRIYSGLLKRGDTVRI
LDTSQSESREDDETPSCEVEEIGLLGGRYVYPVHEAHKGQIVLIKGISSA
YIKSATLYSVKSKEDMKQLKFFKPLDYITEAVFKIVLQPLLPRELPKLLD
ALNKISKYYPGVIIKVEESGEHVILGNGELYMDCLLYDLRASYAKIEIKI
SDPLTVFSESCSNSRLGEENLPGLSISVAAEPMDSKMIQDLSRNTLGKGQ
NCLDIDGIMDNPRKLSKILRTEYGWDSLASRNVWSFYNGNVLINDTLPDE
ISPELLSKYKEQIIQGFYWAVKEGPLAEEPIYGVQYKLLSISVPSDVNID
VMKSQIIPLMKKACYVGLLTAIPILLEPIYEVDITVHAPLLPIVEELMKK
RRGSRIYKTIKVAGTPLLEVRGQVPVIESAGFETDLRLSTNGLGMCQLYF
WHKIWRKVPGDVLDKDAFIPKLKPAPINSLSRDFVMKTRRRKG
Ligand information
>5zwo Chain B (length=175) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aagcagcuuuacagaucaauggcggagggaggucaacaucaagaacugug
ggcgccuauagaacuuauaacgaacaugguucuugccuuuuaccagaacc
auccggguguugucuccauagaaacagguaaagcuguccguuacuguggg
cuugccauauuuuuuggaacuuuuc
...<<<<<<.<<<<.......<<<<..<<<<<.<<<<<<<<<<..<<<<<
<<..>>>>>>>..>>>.........<<<<<<<<...........>>>>>>
>>...>>>>>>>>>>>>......<<<<......>>>>>>>>..>>>>>>>
>.>>.....................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5zwo Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
Resolution3.9 Å
Binding residue
(original residue number in PDB)		K111 K173 I185 D186 R405
Binding residue
(residue number reindexed from 1)		K10 K72 I84 D85 R304
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000349 generation of catalytic spliceosome for first transesterification step
GO:0000387 spliceosomal snRNP assembly
GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071007 U2-type catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zwo, PDBe:5zwo, PDBj:5zwo
PDBsum5zwo
PubMed29794219
UniProtP36048|SN114_YEAST Pre-mRNA-splicing factor SNU114 (Gene Name=SNU114)

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