Structure of PDB 5yu6 Chain C Binding Site BS01

Receptor Information
>5yu6 Chain C (length=1073) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCG
LRLAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANG
TLNILEEENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTE
LVMFILLRLAEDVVTFQTLPPQRRRDIQQTLTQNMERIFSFLLNTLQENV
NKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLL
EILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYILS
AAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGK
YLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRAS
MTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLAC
RLDPKTSFQMAGEWLKYQLSTFSLCSVFSPSFVQWEAMTLFLESVITQMF
RTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPE
FLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQL
VLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFKNYERQKVF
LEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKGLEDPCGLNRARMS
FCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQILKL
LDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPLLE
LNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLATQL
LSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLFTY
LHMRLSQKWQVINQRSLLESQEMLEEQLVRMLTREVMDLITVCCVSELTD
LGKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGT
LLADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRA
VMEQIPEIQKDSLDQFDCKLLNP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5yu6 Structural Basis for Selective Binding of Export Cargoes by Exportin-5
Resolution2.997 Å
Binding residue
(original residue number in PDB)		F1098 F1129
Binding residue
(residue number reindexed from 1)		F1035 F1066
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0070883 pre-miRNA binding
GO:1905172 RISC complex binding
Biological Process
GO:0006405 RNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0010586 miRNA metabolic process
GO:0015031 protein transport
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035281 pre-miRNA export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0042565 RNA nuclear export complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5yu6, PDBe:5yu6, PDBj:5yu6
PDBsum5yu6
PubMed30100359
UniProtQ9HAV4|XPO5_HUMAN Exportin-5 (Gene Name=XPO5)

[Back to BioLiP]