Structure of PDB 5y58 Chain C Binding Site BS01

Receptor Information
>5y58 Chain C (length=548) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHEGILFCIELSETMFKESSDLEYKSPLLEILESLDELMSQLVITRPGTA
IGCYFYYCNREDAKEGIYELFPLRDINATFMKKLNDLLEDLSSGRISLYD
YFMFQQTGSEKQVRLSVLFTFMLDTFLEEIPGQKQLSNKRVFLFTDIDKP
QEAQDIDERARLRRLTIDLFDNKVNFATFFIGYADKPFDNEFYSDILQLG
DSEFDGPSTKPIDAKYIKSRILRKKEVKRIMFQCPLILDEKTNFIVGVKG
YTMYTHEKAGVRYKLVYEHEDIRQEAYSKRKFLNPITGEDVTGKTVKVYP
YGDLDINLSDSQDQIVMEAYTQKDAFLKIIGFRSSSKSIHYFNNIDKSSF
IVPDEAKYEGSIRTLASLLKILRKKDKIAILWGKLKSNSHPSLYTLSPSS
VKDYNEGFYLYRVPFLDEIRKFPSLLSYDDGSEHKLDYDNMKKVTQSIMG
YFNLRDGYNPSDFKNPLLQKHYKVLHDYLLQIETTFDENETPNTKKDRMM
REDDSLRKLYYIRNKILESEKSEDPIIQRLNKYVKIWNMFYKKFNDDN
Ligand information
>5y58 Chain Y (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggacuuauagauggcuaaaaucugagucca
<<<<<<..<<<<.......>>>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5y58 Structural Insights into Yeast Telomerase Recruitment to Telomeres
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H292 E293 K294 V297 R298 Y299 R316 K333 N424 S425 H426 D453 R456
Binding residue
(residue number reindexed from 1)		H256 E257 K258 V261 R262 Y263 R280 K297 N388 S389 H390 D417 R420
Binding affinityPDBbind-CN: Kd=75nM
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042162 telomeric DNA binding
GO:0070034 telomerase RNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000725 recombinational repair
GO:0000727 double-strand break repair via break-induced replication
GO:0006281 DNA repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0030466 silent mating-type cassette heterochromatin formation
GO:0031509 subtelomeric heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0097552 mitochondrial double-strand break repair via homologous recombination
GO:0097695 establishment of protein-containing complex localization to telomere
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005694 chromosome
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y58, PDBe:5y58, PDBj:5y58
PDBsum5y58
PubMed29290466
UniProtP32807|KU70_YEAST ATP-dependent DNA helicase II subunit 1 (Gene Name=YKU70)

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