Structure of PDB 5xsq Chain C Binding Site BS01

Receptor Information
>5xsq Chain C (length=316) Species: 482820 (Lake Victoria marburgvirus - Ozolin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKVILFDTNHQVSICNQIIDAINSGIDLGDLLEGGLLTLCVEHYYNSDKD
KFNTSPIAKYLRDAGYEFDVIKNADATRFLDVIPNEPHYSPLILALKTLE
STESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTVHQEQGIVTYP
NHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSVGQ
TRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLA
RHGEYAPFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGE
QYQQLREAAHDAEVKL
Ligand information
>5xsq Chain D (length=23) Species: 482820 (Lake Victoria marburgvirus - Ozolin) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SYMQQVSEGLMTGKVPIDQVFGA
Receptor-Ligand Complex Structure
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PDB5xsq Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K214 L217 E218 L221 Q222 L230 R235 K247 S251 L253 A254 G257
Binding residue
(residue number reindexed from 1)		K210 L213 E214 L217 Q218 L226 R231 K243 S247 L249 A250 G253
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019074 viral RNA genome packaging
Cellular Component
GO:0019013 viral nucleocapsid

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xsq, PDBe:5xsq, PDBj:5xsq
PDBsum5xsq
PubMed28659479
UniProtQ6UY69|NCAP_MABVO Nucleoprotein (Gene Name=NP)

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