Structure of PDB 5xjc Chain C Binding Site BS01

Receptor Information
>5xjc Chain C (length=862) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTTVYEMD
FLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRTEQERGVGI
KSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDA
AEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHI
VDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTF
GDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKIL
AQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFV
DMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKM
YSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLW
ISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLK
FNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILG
TGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNK
KNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARS
IWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCD
ELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPY
YFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSF
GFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAR
EFMIKTRRRKGL
Ligand information
>5xjc Chain G (length=84) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggaaacggccuccgaacgguaagagccuagcauguagaacugguuaccuc
caggguuuccuugaugaugucauacuuauccugu
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Receptor-Ligand Complex Structure
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PDB5xjc An Atomic Structure of the Human Spliceosome
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R852 H890
Binding residue
(residue number reindexed from 1)		R771 H809
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042220 response to cocaine
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5xjc, PDBe:5xjc, PDBj:5xjc
PDBsum5xjc
PubMed28502770
UniProtQ15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (Gene Name=EFTUD2)

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