Structure of PDB 5x2p Chain C Binding Site BS01

Receptor Information

>5x2p Chain C (length=430) Species: 8090 (Oryzias latipes)

TSEFHLRGDYLIGGLFNIHYVAAANFQRPQAIDCSSKLFILPNYRRFQMM
RFSVEEINNSSSLLPNVSLGYQMFDHCSDIHSFPGIFKLLSVNDLIRPWE
DTGLPNAIGVVGPFTSTHALSIAPIFMTNLFPMVSYGCSGSVFSKENLYP
SFLRTVHSNKDVINAIVGIILNFNWRWVAFLYSDDDFGKDGLEQFKNKIE
DSEICLAFYKAINVNTDYLQVFKQIEEQNIKVIVVFAPKVYAEAVVESAV
QLNVTNKVWIADDGWSLNKKLPSMNGIQNIGTVLGVAQPVVTIPGFTDFI
YSAISQMFCNQKCNCSNLSVKSLLNADPSFSFPVYAAVYAIAHALHNTLR
CGSDRCPKNITVHPHMILEELKKSNFTLLNQTVQFDENGDPKFGSLSVVF
WNSSGNAEEVGSYHFQSSIHLSINKTKIKW

Ligand information

• Ligand ID: GLU
• InChI: InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• InChIKey: WHUUTDBJXJRKMK-VKHMYHEASA-N
• SMILES:
  ACDLabs 12.01: O=C(O)C(N)CCC(=O)O
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)C(C(=O)O)N
  OpenEye OEToolkits 1.7.0: C(CC(=O)O)[C@@H](C(=O)O)N
  CACTVS 3.370: N[C@@H](CCC(O)=O)C(O)=O
  CACTVS 3.370: N[CH](CCC(O)=O)C(O)=O
• Formula: C5 H9 N O4
• Name: GLUTAMIC ACID
• ChEMBL: CHEMBL575060
• DrugBank: DB00142
• ZINC: ZINC000001482113
• PDB chain: 5x2p Chain C Residue 951

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5x2p Structural basis for perception of diverse chemical substances by T1r taste receptors
• Resolution: 2.608 Å
• Binding residue (original residue number in PDB): F140 T141 S142 G163 C164 S165 F213 P264
• Binding residue (residue number reindexed from 1): F114 T115 S116 G137 C138 S139 F187 P238
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:5x2p, PDBe:5x2p, PDBj:5x2p
• PDBsum: 5x2p
• PubMed: 28534491
• UniProt: A0A173M0G2