Structure of PDB 5wvo Chain C Binding Site BS01
Receptor Information
>5wvo Chain C (length=232) Species:
9606
(Homo sapiens) [
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CIQCGLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHKLTC
FSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLG
PINEWWITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYIS
KIVVEFLQSNSDSTYEDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVE
QVESYDEAGDSDEQPIFLTPCMRDLIKLAGVT
Ligand information
>5wvo Chain D (length=19) Species:
9606
(Homo sapiens) [
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RTKQTARKSTGGKAPRCQL
Receptor-Ligand Complex Structure
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PDB
5wvo
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
Resolution
1.997 Å
Binding residue
(original residue number in PDB)
I427 E428 N430 N462 E463 W464 W465 I466 T467 F469 Q517 Q560 S563 Y564 G568 D569 D571 E572
Binding residue
(residue number reindexed from 1)
I68 E69 N71 N103 E104 W105 W106 I107 T108 F110 Q158 Q201 S204 Y205 G209 D210 D212 E213
Enzymatic activity
Enzyme Commision number
2.1.1.37
: DNA (cytosine-5-)-methyltransferase.
External links
PDB
RCSB:5wvo
,
PDBe:5wvo
,
PDBj:5wvo
PDBsum
5wvo
PubMed
29053958
UniProt
P26358
|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)
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